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3,4,5-Trimethoxyphenethylamine (also known as mescaline) is a naturally-occurring classical psychedelic substance of the phenethylamine class. It occurs naturally in the peyote cactus (Lophophora williamsii), San Pedro cactus, Peruvian Torch cactus as well as the Cactaceae plant and the Fabaceae bean families. It grows wild in the Southwestern United States and in Northern Mexico, and has been used as an intimate component of a number of religious traditions amongst the native Indians of these areas.. It is one of the oldest known hallucinogens and the parent compound of the psychedelic phenethylamines, one of the two major subclasses of psychedelic compounds (along with tryptamines).

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Mescaline was first isolated from peyote in 1897 by the German chemist Arthur Heffter. The ritual use of the peyote cactus has occurred for at least 5700 years by Native Americans in Mexico and other mescaline-containing cacti such as the San Pedro have a long history of use in the South American continent, from Peru to Ecuador. Mescaline is an important part of the life’s work of the American chemist Alexander Shulgin, who used it as a starting point for synthesizing dozens of novel psychedelic compounds that are documented in his 1991 book PiHKAL (“Phenethylamines I Have Known and Loved”).

Mescaline Capsule Dosage

Oral Mescaline HCl Dosages
Microdose	50 – 100 mg
Light	100 – 200 mg
Common	200 – 300 mg
Strong	300 – 500 mg
Heavy	500 – 700 mg

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Mescaline Capsules – Research, Pharmacology & Safety Overview

Mescaline is a naturally occurring psychedelic phenethylamine found in certain cactus species, including peyote and several Echinopsis species. Modern research has examined its effects on serotonin receptors, subjective experience, cardiovascular responses, pharmacokinetics, and potential therapeutic applications.

What Is Mescaline?

Mescaline, chemically known as 3,4,5-trimethoxyphenethylamine, is classified as a classic serotonergic psychedelic. Its psychedelic effects are primarily associated with activity at the serotonin 5-HT2A receptor. Researchers continue to investigate its pharmacology and potential applications, although clinical evidence remains limited compared with better-studied compounds.

The scientific literature also examines mescaline’s pharmacokinetics, metabolism, cardiovascular effects, psychological effects, and potential interactions with other substances.

Research & Safety

Contemporary studies indicate that mescaline can produce significant subjective and autonomic effects. Research involving screened healthy participants has reported moderate transient autonomic changes, while researchers emphasize that safety data remain limited for people with underlying medical or psychiatric conditions.

Because laws surrounding mescaline and mescaline-containing plants vary considerably by jurisdiction, readers should verify applicable regulations before possessing or handling such substances. In the United States, the DEA identifies peyote as a Schedule I substance.